4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine MI-2

Name	MI-2
Synonyms	MI2 MI 2 MI-2 Menin-MLL Inhibitor MENIN-MLL INHIBITOR 2 Menin-MLL inhibitor 2 MI-2 (Menin-MLL Inhibitor) 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyriMidine 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-propyl- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine MI-2
CAS	1271738-62-5

Molecular Formula	C18H25N5S2
Molar Mass	375.55
Storage Condition	-20℃
In vitro study	In HEK293 cells, MI-2 accessed the protein target and effectively inhibited the interaction by menin-MLL-AF9. MI-2 the MLL fusion protein-mediated leukemic transformation is effectively blocked by down-regulating the expression of target genes essential for the tumorigenic activity of the MLL fusion protein. For human MLL leukemia cell lines containing different MLL translocations, MI-2 was also effective in blocking cell proliferation and inducing apoptosis. in HEK293 cells, MI-2 accessed the protein target and effectively inhibited the interaction by menin-MLL-AF9. MI-2 the MLL fusion protein-mediated leukemic transformation is effectively blocked by down-regulating the expression of target genes essential for the tumorigenic activity of the MLL fusion protein. For human MLL leukemia cell lines containing different MLL translocations, MI-2 was also effective in blocking cell proliferation and inducing apoptosis.

Last Update：2024-01-02 23:10:35

biological activity	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor with IC50 of 446 nM. MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor with IC50 of 446 nM.
in vitro study	in HEK293 cells, MI-2 access protein targets and effectively inhibit menin-MLL-AF9 interactions. MI-2 By down-regulating the expression of target genes necessary for the tumorigenic activity of MLL fusion protein, it effectively blocks the transformation of leukemia mediated by MLL fusion protein. For human MLL leukemia cell lines containing different MLL translocation, MI-2 can also effectively block cell proliferation and induce cell apoptosis. in HEK293 cells, MI-2 access protein targets and effectively inhibit menin-MLL-AF9 interactions. MI-2 By down-regulating the expression of target genes necessary for the tumorigenic activity of MLL fusion protein, it effectively blocks the transformation of leukemia mediated by MLL fusion protein. For human MLL leukemia cell lines containing different MLL translocation, MI-2 can also effectively block cell proliferation and induce cell apoptosis.
target	TargetValue Menin-MLL interaction 446 nM
Target	Value
Menin-MLL interaction (Cell-free assay)	446 nM

Last Update：2024-04-10 22:29:15

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Product Name: MI-2 Visit Supplier Webpage Request for quotation
CAS: 1271738-62-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine MI-2 Request for Quotation